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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often focused on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of commonly available equipment.

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Pragmatic is a software company that offers a broad range of casino games on online gambling platforms. Pragmatic's iGaming software is used by top operators as well as land-based casinos. The company offers front-end site design tools, analysis tools and promotions, marketing security payment systems, customer service, and bug reporting. The company also provides an environment that is safe and secure with high-quality graphics, gaming and security.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid, and it also helps to reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the trial design.

Pragmatic Play is also a major player on the live casino market, providing a wide selection of table games that are classic such as Blackjack and Roulette in a variety of versions. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic gaming experience as well a full variety of betting options via virtual. The company also offers a variety of games that make online gambling fun and interactive. Some of these shows are broadcast live, while others include famous people from the industry.

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Legality

Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in a variety of languages. It has established itself as one of the most popular gaming platforms in the casino industry despite its relatively young age. Wolves is one of the most recent releases that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to inform their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study which includes recruitment, design, delivery of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.